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2024-11-25

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cc-by (c) Pinteac, R. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/217902

Chitinase 3-like 1 is neurotoxic in multiple sclerosis patient-derived cortical neurons

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https://doi.org/10.1002/ctm2.70125

Resum

We are pleased to present our latest findings regarding the neurotoxic role of Chitinase 3-like 1 (CHI3L1) in multiple sclerosis (MS). CHI3L1, a 40 kD glycoprotein, is primarily produced by activated astrocytes and microglia in the central nervous system (CNS), and it has garnered considerable attention due to its implications in inflammation and tissue remodelling.1 It is notably increased in several conditions, including MS, and accumulating evidence supports CHI3L1 as a biomarker in early MS, with elevated cerebrospinal fluid (CSF) levels associated with increased disability risk.2, 3 This association led us to investigate whether CHI3L1 simply reflects glial activation or if it exerts direct neurotoxicity. Our prior work in murine neurons demonstrated CHI3L1's neurotoxic effects,4 prompting us to explore its impact on MS patient-derived human induced pluripotent stem cells (hiPSC). Here, we aim to characterize these effects at both molecular and functional levels, further exploring CHI3L1's potential as a biomarker and therapeutic target for MS.

Matèries

Esclerosi múltiple, Quitina, Neurones

Matèries (anglès)

Multiple sclerosis, Chitin, Neurons

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Col·leccions

Articles publicats en revistes (Física de la Matèria Condensada)
Articles publicats en revistes (Institut de Recerca en Sistemes Complexos (UBICS))

Citació

PINTEAC, R., et al. Chitinase 3-like 1 is neurotoxic in multiple sclerosis patient-derived cortical neurons. Clinical and Translational Medicine. 2024. Vol. 14. ISSN 2001-1326. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/217902

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