Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193984
Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regular intracellular conditions. Homogeneous functionalization in suspension was achieved, where the open-chain structure exhibits a more dense packing than cyclic analogues. The microparticles internalized induce high cytotoxicity per particle in cancerous HeLa cells, and the less densely packed functionalization using cyclophanes promotes higher cytotoxicity per bipy than with open-chain analogues. The self-renewing ability of the particles and their proximity to cell membranes may account for increased lipid peroxidation, achieving toxicity at much lower concentrations than that in solution and in less time, inducing highly efficient cytotoxicity in cancerous cells. Keywords: HeLa cells; bipyridinium; cancer; cytotoxicity; lipid peroxidation; polysilicon microparticles.
Matèries
Matèries (anglès)
Citació
Citació
LIMÓN, David, HORNICKΓ, Jessica e., CAI, Kang, BELDJOUDI, Yassine, PLAZA, José a., DUCH, Marta, PÉREZ GARCÍA, M. lluïsa (maria lluïsa), STODDART, J. frasser. Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells. _ACS Nano_. 2022. Vol. 16, núm. 5358-5375. [consulta: 23 de gener de 2026]. ISSN: 1936-0851. [Disponible a: https://hdl.handle.net/2445/193984]