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2015-09

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A strategy for the triarylation of pyrrolopyrimidines by using microwave-promoted cross-coupling reactions

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Recurs relacionat

http://dx.doi.org/10.1002/ejoc.201500625

Resum

New pyrrolo[2,3-d]pyrimidines that have aryl groups at the 2-, 4-, and 6-positions were prepared by the arylation reaction of 4-chloro-7-methyl-2-(methylthio)-6-phenylpyrrolo[2,3-d]pyrimidine (6) and the corresponding arylboronic acid under Suzuki-Miyaura conditions followed by a second arylation under Liebeskind-Srogl cross-coupling conditions. A parallel study that began with the C-2 chemoselective arylation of 6 under Liebeskind-Srogl conditions followed by a Suzuki-Miyaura coupling at C-4 was carried out, and the results of each route were compared. All of the tranformations were performed under microwave irradiation.

Matèries

Compostos heterocíclics, Nitrogen, Química orgànica, Reaccions químiques

Matèries (anglès)

Heterocyclic compounds, Nitrogen, Organic chemistry, Chemical reactions

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citació

PRIEUR, Vanessa, PUJOL DILMÉ, M. Dolors i GUILLAUMET, Gérald. A strategy for the triarylation of pyrrolopyrimidines by using microwave-promoted cross-coupling reactions. European Journal of Organic Chemistry. 2015. Vol. 29, núm. 6547-6556. ISSN 1434-193X. [consulta: 8 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/96646

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