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A strategy for the triarylation of pyrrolopyrimidines by using microwave-promoted cross-coupling reactions
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New pyrrolo[2,3-d]pyrimidines that have aryl groups at the 2-, 4-, and 6-positions were prepared by the arylation reaction of 4-chloro-7-methyl-2-(methylthio)-6-phenylpyrrolo[2,3-d]pyrimidine (6) and the corresponding arylboronic acid under Suzuki-Miyaura conditions followed by a second arylation under Liebeskind-Srogl cross-coupling conditions. A parallel study that began with the C-2 chemoselective arylation of 6 under Liebeskind-Srogl conditions followed by a Suzuki-Miyaura coupling at C-4 was carried out, and the results of each route were compared. All of the tranformations were performed under microwave irradiation.
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PRIEUR, Vanessa, PUJOL DILMÉ, M. Dolors and GUILLAUMET, Gérald. A strategy for the triarylation of pyrrolopyrimidines by using microwave-promoted cross-coupling reactions. European Journal of Organic Chemistry. 2015. Vol. 29, num. 6547-6556. ISSN 1434-193X. [consulted: 6 of October of 2026]. Available at: https://hdl.handle.net/2445/96646