Carregant...
Tipus de document
Treball de fi de grauData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222776
Visible-Light-Induced Functionalization of Oxindole Enol Ethers via EDA Complex Photoactivation
Títol de la revista
Autors
ISSN de la revista
Títol del volum
Resum
Light-mediated reactions offer a powerful platform for exploring chemical reactivity through controlled photoexcitation. This project focuses on advancing photoinduced reactions via electron donor-acceptor (EDA) complex activation, where interactions between an electron-rich donor and an electron-deficient acceptor generate reactive radicals under visible-light irradiation. Crucially, this approach operates without external catalysts—such as traditional metal-based photocatalysts—or sacrificial additives, enhancing synthetic efficiency.
Central to our study is the functionalization of oxindoles, a privileged scaffold in medicinal chemistry due to the potent bioactivity of its derivatives. To achieve this, we designed and synthesized an oxindole-derived enol ether (donor 1) and paired it with Katritzky salts (acceptors 3 and 4) as complementary EDA complex partners. UV-visible spectroscopy confirmed EDA complex formation through the characteristic charge-transfer band (CT), while also identifying the optimal irradiation wavelength to maximize product formation and minimize byproduct generation. These findings establish a foundation for developing a mild, efficient, and catalyst-free methodology for oxindole functionalization. Future work will expand the scope of this reactivity and refine reaction conditions to enhance synthetic utility.
Descripció
Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2025, Tutor: Alberto Vega Peñaloza
Matèries
Matèries (anglès)
Citació
Col·leccions
Citació
SANTIAGO ABELLEIRA, Danae. Visible-Light-Induced Functionalization of Oxindole Enol Ethers via EDA Complex Photoactivation. [consulta: 28 de novembre de 2025]. [Disponible a: https://hdl.handle.net/2445/222776]