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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123393
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links
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Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1-fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration.
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GONZÁLEZ TARRAGÓ, Víctor, et al. Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links. Molecular Biology of the Cell. 2017. Vol. 28, num. 14, pags. 1847-1852. ISSN 1059-1524. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/123393