Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123393
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1-fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration.
Matèries (anglès)
Citació
Citació
GONZÁLEZ TARRAGÓ, Víctor, ELOSEGUI ARTOLA, Alberto, BAZELLIÈRES, Elsa, ORIA, Roger, PÉREZ GONZÁLEZ, Carlos, ROCA-CUSACHS SOULERE, Pere. Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links. _Molecular Biology of the Cell_. 2017. Vol. 28, núm. 14, pàgs. 1847-1852. [consulta: 20 de gener de 2026]. ISSN: 1059-1524. [Disponible a: https://hdl.handle.net/2445/123393]