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221899.pdf (1.03 MB)

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2020-03-01

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cc-by-nc-nd (c) Elsevier B.V., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225914

A novel methodology for the determination of neutral perfluoroalkyl and polyfluoroalkyl substances in water by gas chromatographyatmospheric pressure photoionisation-high resolution mass spectrometry

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https://doi.org/10.1016/j.aca.2019.12.004

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Here, we developed and validated a new gas chromatography-atmospheric pressure photoionisation high-resolution mass spectrometry (GC-APPI-HRMS) method combined with headspace solid-phase microextraction (HS-SPME) for the determination of neutral perfluoroalkyl and polyfluoroalkyl substances (PFASs) in water samples. The method includes fluorotelomer olefins (FTOs), fluorotelomer alcohols (FTOHs), fluoroctanesulfonamides (FOSAs) and sulfonamido-ethanols (FOSEs). The feasibility of the GC-APPI interface for the ionisation of the target compounds was evaluated, achieving the best results using negative-ion dopant-assisted ionisation with acetone and a source and capillary temperatures of 225 oC and 175 oC, respectively. Under optimal conditions, FTOs and FTOHs mass spectra showed intense in-source CID fragment ions from the fluoroalkyl chain but also the superoxide [M+O2]-· adduct ion. For FOSAs, [M-H]- was the main ion generated, while FOSEs mass spectra showed fragment ions corresponding to the different cleavages of the functional group. The high ionisation efficiency achieved with the GC-APPI interface provided limits of the detection lower than those obtained using traditional GC-MS ionisation techniques, with a high sensitivity, selectivity and precision. For water analysis, a fast and simple HS-SPME procedure was developed, avoiding evaporation steps, which could lead to the loss of the most volatile compounds. The developed HS-SPME GC-APPI-HRMS method showed a good analytical performance for the analysis of river water samples, providing very low limits of detection (0.02e15 ng L 1), good repeatability (RSD < 11%) and trueness (relative error < 12%).

Matèries

Cromatografia de gasos, Ionització, Espectrometria de masses

Matèries (anglès)

Gas chromatography, Ionization, Mass spectrometry

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Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citació

AYALA CABRERA, Juan Francisco, et al. A novel methodology for the determination of neutral perfluoroalkyl and polyfluoroalkyl substances in water by gas chromatographyatmospheric pressure photoionisation-high resolution mass spectrometry. Analytica Chimica Acta. 2020. Vol. 1100, num. 97-106. ISSN 0003-2670. [consulted: 20 of August of 2026]. Available at: https://hdl.handle.net/2445/225914

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