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Accepted version

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2020-07-19

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/211921

Emerging Agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline?

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https://doi.org/10.1080/13543784.2020.1793955

Abstract

ntroduction: Chagas disease treatment relies on the lengthy administration of benznidazole and/or nifurtimox, which have frequent toxicity associated. The disease, caused by the parasite Trypanosoma cruzi, is mostly diagnosed at its chronic phase when life-threatening symptomatology manifest in approximately 30% of those infected. Considering that both available drugs have variable efficacy by then, and there are over 6 million people infected, there is a pressing need to find safer, more efficacious drugs. Areas covered: We provide an updated view of the path to achieve the aforementioned goal. From state-of-the-art in vitro and in vivo assays based on genetically engineered parasites that have allowed high throughput screenings of large chemical collections, to the unfulfilled requirement of having treatment-response biomarkers for the clinical evaluation of drugs. In between, we describe the most promising pre-clinical hits and the landscape of clinical trials with new drugs or new regimens of existing ones. Moreover, the use of monkey models to reduce the pre-clinical to clinical attrition rate is discussed. Expert opinion: In addition to the necessary research on new drugs and much awaited biomarkers of treatment efficacy, a key step will be to generalize access to diagnosis and treatment and maximize efforts to impede transmission.

Subject

Malaltia de Chagas, Malalties parasitàries

Subject (English)

Chagas' disease, Parasitic diseases

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Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
Articles publicats en revistes (ISGlobal)

Citation

MARTINEZ-PEINADO, Nieves, et al. Emerging Agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline?. Expert Opinion on Investigational Drugs. 2020. Vol. 29, num. 9, pags. 947-959. ISSN 1354-3784. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/211921

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