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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183848
The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance
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The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)β/δ show promise. Remarkably, most of the antidiabetic effects of PPARβ/δ agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARβ/δ-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARβ/δ-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus.
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AGUILAR-RECARTE, David, PALOMER TARRIDAS, Francesc xavier, WAHLI, Walter, VÁZQUEZ CARRERA, Manuel. The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance. _International Journal of Molecular Sciences_. 2021. Vol. 22, núm. 16, pàgs. 8555. [consulta: 25 de gener de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/183848]