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cc-by (c) Malgaretti, Paolo et al., 2013
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/51743

Entropic transport in confined media: a challenge for computational studies in biological and soft-matter systems

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Transport in small-scale biological and soft-matter systems typically occurs under confinement conditions in which particles proceed through obstacles and irregularities of the boundaries that may significantly alter their trajectories. A transport model that assimilates the confinement to the presence of entropic barriers provides an efficient approach to quantify its effect on the particle current and the diffusion coefficient. We review the main peculiarities of entropic transport and treat two cases in which confinement effects play a crucial role, with the appearance of emergent properties. The presence of entropic barriers modifies the mean first-passage time distribution and therefore plays a very important role in ion transport through micro- and nano-channels. The functionality of molecular motors, modeled as Brownian ratchets, is strongly affected when the motor proceeds in a confined medium that may constitute another source of rectification. The interplay between ratchet and entropic rectification gives rise to a wide variety of dynamical behaviors, not observed when the Brownian motor proceeds in an unbounded medium. Entropic transport offers new venues of transport control and particle manipulation and new ways to engineer more efficient devices for transport at the nanoscale.

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MALGARETTI, Paolo, PAGONABARRAGA MORA, Ignacio and RUBÍ CAPACETI, José Miguel. Entropic transport in confined media: a challenge for computational studies in biological and soft-matter systems. Frontiers in Physics. 2013. Vol. 1, num. 21, pags. 1-9. ISSN 2296-424X. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/51743

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