Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model

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dc.contributor.authorSoriano-Meseguer, Sara
dc.contributor.authorFuguet i Jordà, Elisabet
dc.contributor.authorPort, Adriana
dc.contributor.authorRosés Pascual, Martí
dc.date.accessioned2024-03-05T18:46:15Z
dc.date.available2024-03-05T18:46:15Z
dc.date.issued2023-06-30
dc.date.updated2024-03-05T18:46:15Z
dc.description.abstractTwo parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtained equations have been compared to the ones already established for other PAMPA membranes using statistical tools. The results indicate that both skin membranes are similar to each other in their physicochemical properties. However, they are different from other PAMPA membranes (e.g., intestinal absorption and blood– brain PAMPAs), mainly in terms of hydrophobicity and hydrogen bonding properties. Next, all PAMPA membranes have been compared to relevant biological processes also characterized through the solvation parameter model. The results highlight that skin-PAMPA membranes are a very good choice to emulate skin permeability.
dc.format.extent12 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec740911
dc.identifier.issn2077-0375
dc.identifier.urihttps://hdl.handle.net/2445/208414
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/https://doi.org/10.3390/membranes13070640
dc.relation.ispartofMembranes, 2023, vol. 13, p. 1-12
dc.relation.urihttps://doi.org/https://doi.org/10.3390/membranes13070640
dc.rightscc-by (c) Soriano-Meseguer, S. et al., 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject.classificationPermeabilitat
dc.subject.classificationAbsorció intestinal
dc.subject.classificationSolvatació
dc.subject.otherPermeability
dc.subject.otherIntestinal absorption
dc.subject.otherSolvation
dc.titleEvaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Enginyeria Química i Química Analítica)
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