Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model

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dc.contributor.authorGriñán Ferré, Christian
dc.contributor.authorCorpas Expósito, Rubén
dc.contributor.authorPuigoriol Illamola, Dolors
dc.contributor.authorPalomera Ávalos, Verónica
dc.contributor.authorSanfeliu i Pujol, Coral
dc.contributor.authorPallàs i Llibería, Mercè, 1964-
dc.date.accessioned2021-02-25T08:31:45Z
dc.date.available2021-02-25T08:31:45Z
dc.date.issued2018-04-02
dc.date.updated2021-02-25T08:31:45Z
dc.description.abstractEpigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than one generation. Furthermore, derangement of age-related epigenetic signaling is appearing as a significant risk factor for illnesses of aging, including neurodegeneration and Alzheimer's disease (AD). In addition, better knowledge of epigenetic mechanisms might provide hints and clues in the triggering and progression of AD. Intense research in experimental models suggests that molecular interventions for modulating epigenetic mechanisms might have therapeutic applications to promote cognitive maintenance through an advanced age. The SAMP8 mouse is a senescence model with AD traits in which the study of epigenetic alterations may unveil epigenetic therapies against the AD. Keywords: Aging, DNA methylation, epigenetics, histone modification, neurodegeneration
dc.format.extent21 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec680647
dc.identifier.issn1387-2877
dc.identifier.pmid29562529
dc.identifier.urihttps://hdl.handle.net/2445/174290
dc.language.isoeng
dc.publisherIOS Press
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3233/JAD-170664
dc.relation.ispartofJournal of Alzheimer's Disease, 2018, vol. 62, num. 3, p. 943-963
dc.relation.urihttps://doi.org/10.3233/JAD-170664
dc.rights(c) Griñán Ferré, Christian et al., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationMalaltia d'Alzheimer
dc.subject.classificationMalalties neurodegeneratives
dc.subject.classificationEnvelliment
dc.subject.classificationEpigenètica
dc.subject.otherAlzheimer's disease
dc.subject.otherNeurodegenerative Diseases
dc.subject.otherAging
dc.subject.otherEpigenetics
dc.titleUnderstanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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