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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/133942
Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clone II and III in Lima, Peru
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Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 nonduplicate clinical samples of A. baumannii collected from February 2014 through April 2016 at two tertiary care hospitals in Lima. Almost all isolates were carbapenem-resistant (97.5%), and susceptibility only remained high for colistin (95%). Pulsed-field gel electrophoresis showed two main clusters spread between both hospitals: cluster D containing 51 isolates (63.8%) associated with sequence type 2 (ST2) and carrying OXA-72, and cluster F containing 13 isolates (16.3%) associated with ST79 and also carrying OXA-72. ST2 and ST79 were endemic in at least one of the hospitals. ST1 and ST3 OXA-23-producing isolates were also identified. They accounted for sporadic hospital isolates. Interestingly, two isolates carried the novel OXA-253 variant of OXA-143 together with an upstream novel insertion sequence (ISAba47). While the predominant A. baumannii lineages in Latin America are linked to ST79, ST25, ST15, and ST1 producing OXA-23 enzymes, we report the emergence of highly resistant ST2 (IC-II) isolates in Peru producing OXA-72 and the first identification of ST3 isolates (IC-III) in Latin America, both considered a serious threat to public health worldwide.
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LEVY-BLITCHTEIN, Sául, ROCA SUBIRÀ, Ignasi, PLASENCIA-REBATA, Stefany, VICENTE-TABOADA, William, VELÁSQUEZ-POMAR, Jorge, MUÑOZ LÓPEZ, Laura, MORENO-MORALES, Javier, PONS, Maria j., DEL VALLE-MENDOZA, Juana, VILA ESTAPÉ, Jordi. Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clone II and III in Lima, Peru. _Emerging Infectious Diseases_. 2018. Vol. 7, núm. 1, pàgs. 119. [consulta: 23 de gener de 2026]. ISSN: 1080-6040. [Disponible a: https://hdl.handle.net/2445/133942]