Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

681197.pdf (1.33 MB)

Document type

Article

Version

Published version

Publication date

2018-07-04

Publication license

cc by (c) Levy-Blitchtein, Sául et al., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/133942

Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clone II and III in Lima, Peru

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1038/s41426-018-0127-9

Abstract

Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 nonduplicate clinical samples of A. baumannii collected from February 2014 through April 2016 at two tertiary care hospitals in Lima. Almost all isolates were carbapenem-resistant (97.5%), and susceptibility only remained high for colistin (95%). Pulsed-field gel electrophoresis showed two main clusters spread between both hospitals: cluster D containing 51 isolates (63.8%) associated with sequence type 2 (ST2) and carrying OXA-72, and cluster F containing 13 isolates (16.3%) associated with ST79 and also carrying OXA-72. ST2 and ST79 were endemic in at least one of the hospitals. ST1 and ST3 OXA-23-producing isolates were also identified. They accounted for sporadic hospital isolates. Interestingly, two isolates carried the novel OXA-253 variant of OXA-143 together with an upstream novel insertion sequence (ISAba47). While the predominant A. baumannii lineages in Latin America are linked to ST79, ST25, ST15, and ST1 producing OXA-23 enzymes, we report the emergence of highly resistant ST2 (IC-II) isolates in Peru producing OXA-72 and the first identification of ST3 isolates (IC-III) in Latin America, both considered a serious threat to public health worldwide.

Subject

Bacteris patògens, Medicina intensiva

Subject (English)

Pathogenic bacteria, Critical care medicine

Citation

Collections

Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (ISGlobal)

Citation

LEVY-BLITCHTEIN, Sául, et al. Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clone II and III in Lima, Peru. Emerging Infectious Diseases. 2018. Vol. 7, num. 1, pags. 119. ISSN 1080-6040. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/133942

Export metadata

JSON - METS

Share record