Simulated pulling experiments of an RNA hairpin

Abstract

Different studies have shown how to approach the folding process of the RNA, with optical tweezers. On this basis, we've present a simple case of the simulation of a single RNA hairpin pulling experiment. During this work, the experimental device simulated is described and modeled, where also its elastic properties have been considered, as they are an important part of the study. Subsequently, information is extracted from the data and the results obtained on the simulation, related with the thermodynamics of kinetics the unfolding/folding of RNA molecule. The simulated model reproduces qualitatively the experimental results.