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MarquesJ_Nanomedicine_2017.pdf (1.38 MB)

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2017-02

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cc by (c) Marques et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/135361

Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

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Recurs relacionat

http://dx.doi.org/10.1016/j.nano.2016.09.010

Resum

The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.

Matèries

Malària, Nanomedicina

Matèries (anglès)

Malaria, Nanomedicine

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Articles publicats en revistes (ISGlobal)

Citació

MARQUES, Joana, et al. Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery. Nanomedicine: Nanotechnology. Biology and Medicine. Vol.  2017, num. 13, pags. 2. ISSN 1549-9634. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/135361

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