Solubility-pH profiles of a free base and its salt: sibutramine as a case study

Vista senzilla d'ítem
dc.contributor.authorLucero Borja, Diego Sebastián
dc.contributor.authorCastilla, Òscar
dc.contributor.authorBarbas Cañero, Rafael
dc.contributor.authorSubirats i Vila, Xavier
dc.contributor.authorRàfols Llach, Clara
dc.date.accessioned2022-04-13T15:56:12Z
dc.date.available2022-04-13T15:56:12Z
dc.date.issued2017-12-24
dc.date.updated2022-04-13T15:56:12Z
dc.description.abstractIn the present study the solubility-pH profiles of sibutramine free base and its hydrochloride salt were determined in the pH range between 2.0 and 9.5 by means of the recommended shake-flask method, and the solids collected were dried and studied by X-ray diffraction in order to elucidate their free base or salt structure. Above pHmax (or Gibbs pKa) the solid collected was always identified as free base, whatever the sibutramine species (free base or hydrochloride salt) initially solved. However, in the pH range below pHmax different solids were isolated depending on the buffers employed.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec675091
dc.identifier.issn1848-7718
dc.identifier.urihttps://hdl.handle.net/2445/184906
dc.language.isoeng
dc.publisherIAPC Publishing
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.5599/admet.5.4.452
dc.relation.ispartofADMET & DMPK, 2017, vol. 5, num. 4, p. 253-256
dc.relation.urihttps://doi.org/10.5599/admet.5.4.452
dc.rightscc-by (c) Lucero Borja, Diego Sebastián et al., 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject.classificationSolubilitat
dc.subject.classificationSals
dc.subject.classificationPotenciometria
dc.subject.otherSolubility
dc.subject.otherSalts
dc.subject.otherPotentiometry
dc.titleSolubility-pH profiles of a free base and its salt: sibutramine as a case study
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
675091.pdf
Mida:
550 KB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Enginyeria Química i Química Analítica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))