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Collective dynamics of interacting molecular motors
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The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N * 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.
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CAMPÀS, O., et al. Collective dynamics of interacting molecular motors. Physical Review Letters. 2006. Vol. 97, num. 3, pags. 038101-1-038101-4. ISSN 0031-9007. [consulted: 28 of June of 2026]. Available at: https://hdl.handle.net/2445/12844