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2008

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/232485

Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: Glutathione reductase as a target

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The aim of this study was to investigate biochemical changes in juvenile carp (Cyprinus carpio) exposed to zinc chloride (10, 30 and 100 μM) for a period of 48 h. Zinc exposure caused a concentration-dependent reduction in glutathione reductase (GR) activity in gills, liver and brain. Gill glutathione S-transferase (GST) was reduced when animals were exposed to the highest concentration of 100 μM zinc. The phosphorylation of p38MAPK increased in the brain of fish exposed to zinc 100 μM, while phosphorylation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2) and c-Jun N-terminal protein kinase 1/2 (JNK1/2) remained unchanged. Expression of proteins HSP60 and HSP70 were not affected by zinc exposure. Considering the significant concentration-dependent inhibition of GR in all tissues analyzed, this enzyme could be a potential biomarker of exposure to zinc, which has to be confirmed.

Recurs relacionat

https://doi.org/10.1016/j.marenvres.2008.02.031

Matèries

Zinc, Bioquímica, Contaminació

Matèries (anglès)

Zinc, Biochemistry, Pollution

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Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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FRANCO, Jeferson L., et al. Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: Glutathione reductase as a target. Marine Environmental Research. 2008. Vol. 66, num. 1, pags. 88-89. ISSN 0141-1136. [consulted: 6 of November of 2026]. Available at: https://hdl.handle.net/2445/232485

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