Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition

and brown), serum and faecal samples from our previous study and present new

biochemical, faecal metabolomic and microbiome data.

We show that oral administration of mirabegron

significantly increases the expression of uncoupling protein 1 in brown

adipose tissue and β3-Adrenergic receptor protein in perigonadal white

adipose and liver tissues. Furthermore, mirabegron treatment changes the

relative abundance of several genus and families of rat faecal microbiota,

albeit without restoring the global biodiversity and evenness indexes observed

in control rats, as well as faecal bile acids composition. These changes are

probably due to a direct effect of mirabegron on the gut microbiome, rather

than being mediated by changes in bile acid induced by drug treatment.