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2022-03-28

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cc-by (c) Ferrer Fábrega, Joana et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185546

Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study

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https://doi.org/10.3389/ti.2022.10419

Resum

Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis,

Matèries

Trasplantament d'òrgans, Conservació d'òrgans, Pàncrees

Matèries (anglès)

Transplantation of organs, Preservation of organs, Pancreas

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Col·leccions

Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

FERRER FÁBREGA, Joana, FOLCH I PUY, Emma, LOZANO SALVATELLA, Juan josé, VENTURA AGUIAR, Pedro, CÁRDENAS, Gabriel, PAREDES, David, GARCÍA CRIADO, Ángeles, BOMBÍ, Josep antoni, GARCÍA PÉREZ, Rocío, LÓPEZ BOADO, Miguel ángel, RULL, Ramón, ESMATJES MOMPÓ, Enric, RICART BRULLES, Ma. josé, DIEKMANN, Fritz, FONDEVILA CAMPO, Constantino, FERNÁNDEZ CRUZ, Laureano, FUSTER OBREGÓN, Josep, GARCÍA-VALDECASAS SALGADO, Juan carlos. Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study. _Transplant International_. 2022. Vol. 35, núm. 10419. [consulta: 23 de gener de 2026]. ISSN: 0934-0874. [Disponible a: https://hdl.handle.net/2445/185546]

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