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2019-01

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cc by (c) van Belkum, Alex et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/132505

Developmental roadmap for antimicrobial susceptibility testing systems

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https://doi.org/10.1038/s41579-018-0098-9

Resum

Antimicrobial susceptibility testing (AST) technologies help to accelerate the initiation of targeted antimicrobial therapy for patients with infections and could potentially extend the lifespan of current narrow-spectrum antimicrobials. Although conceptually new and rapid AST technologies have been described, including new phenotyping methods, digital imaging and genomic approaches, there is no single major, or broadly accepted, technological breakthrough that leads the field of rapid AST platform development. This might be owing to several barriers that prevent the timely development and implementation of novel and rapid AST platforms in health-care settings. In this Consensus Statement, we explore such barriers, which include the utility of new methods, the complex process of validating new technology against reference methods beyond the proof-of-concept phase, the legal and regulatory landscapes, costs, the uptake of new tools, reagent stability, optimization of target product profiles, difficulties conducting clinical trials and issues relating to quality and quality control, and present possible solutions

Matèries

Tests de sensibilitat microbiològica, Malalties infeccioses

Matèries (anglès)

Microbial sensitivity tests, Communicable diseases

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Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (ISGlobal)

Citació

VAN BELKUM, Alex, BACHMANN, Till t., LÜDKE, Gerd h., LISBY, Jan gorm, KAHLMETER, Gunnar, MOHESS, Allan, BECKER, Karsten, HAYS, John p., WOODFORD, Neil, MITSAKAKIS, Konstantinos, MORAN-GILAD, Jacob, VILA ESTAPÉ, Jordi, PETER, Harald, REX, John h., DUNNE JR., Wm. michael. Developmental roadmap for antimicrobial susceptibility testing systems. _Nature Reviews Microbiology_. 2019. Vol. 17, núm. 51-62. [consulta: 24 de gener de 2026]. ISSN: 1740-1526. [Disponible a: https://hdl.handle.net/2445/132505]

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