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Garcia_J_Sci_Rep_2020.pdf (1.74 MB)

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2020

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cc by (c) Garcia, Juan Ignacio et al, 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183610

Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out

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http://dx.doi.org/ 10.1038/s41598-020-71784-3

Resum

Tuberculosis (TB) misdiagnosis remains a public health concern, especially among people living with HIV (PLHIV), given the high mortality associated with missed TB diagnoses. The main objective of this study was to describe the\xC2\xA0all-cause mortality, TB incidence rates and their\xC2\xA0associated risk factors in a cohort of PLHIV with presumptive TB in whom TB was initially ruled out. We retrospectively followed a cohort of PLHIV with presumptive TB over a 2\xC2\xA0year-period in a rural district in Southern Mozambique. During the study period 382 PLHIV were followed-up. Mortality rate was 6.8/100 person-years (PYs) (95% CI 5.2-9.2) and TB incidence rate was 5.4/100 PYs (95% CI 3.9-7.5). Thirty-six percent of deaths and 43% of TB incident cases occurred in the first 12\xC2\xA0months of the follow up. Mortality and TB incidence rates in the 2-year period after TB was initially ruled out was very high. The\xC2\xA0TB diagnostic work-up and linkage to HIV\xC2\xA0care should be strengthened to decrease TB burden and all-cause mortality among PLHIV with presumptive TB.

Matèries

Persones seropositives, Tuberculosi

Matèries (anglès)

HIV-positive persons, Tuberculosis

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Articles publicats en revistes (ISGlobal)

Citació

GARCIA, Juan ignacio, MAMBUQUE, Edson, NGUENHA, Dinis, VILANCULO, Faustino, SACOOR, Charfudin, SEQUERA BUZARQUIS, Victor guillermo, FERNÁNDEZ QUEVEDO, Manuel, LERROUX-LA PIERRE, Maxime, CHICONELA, Helio, FAIFE, Luis a., RESPEITO, Durbal, SAAVEDRA, Belén, NHAMPOSSA, Tacilta, LÓPEZ VARELA, Elisa, GARCÍA-BASTEIRO, Alberto l.. Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out. _Scientific Reports_. 2020. Vol.  vol 10. [consulta: 25 de febrer de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/183610]

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