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2022-06-22

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cc-by-nc (c) Ciurana, Neus et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/191742

mRNA expression of myosin heavy chain isoforms in the sphenomandibularis portion of the temporalis muscle

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Abstract

The main objective of this study was to analyze by real-time quantitative polymerase chain reaction (RT-qPCR) the expression patterns of the myosin heavy chain (MHC) isoforms (MHC-I, MHC-IIa, MHC-IIx) in the sphenomandibularis portion of the temporalis muscle. We expected to find differences between the sphenomandibularis and the other portions of the temporalis that could be related to the functional characteristics of the sphenomandibularis identified by electromyography. We dissected the right temporalis muscle of ten adult human individuals (five men and five women). Samples of the anterior and posterior temporalis and of the sphenomandibularis portion were obtained from each dissected muscle. These samples were analyzed by RT-qPCR to determine the percentages of expression of the MHC-I, MHC-IIa and MHC-IIx isoforms. No significant differences were identified between the anterior and the posterior temporalis in the expression patterns of the MHC-I, MHC-IIa and MHC-IIx isoforms. However, there were significant differences between the sphenomandibularis and the anterior temporalis. Specifically, the sphenomandibularis portion had a higher percentage of expression of the MHC-I isoform (P=0.04) and a lower percentage of expression of the MHC-IIx isoform (P=0.003). The pattern of expression that we observed in the sphenomandibularis reflects a greater resistance to fatigue, a lower contraction speed, and a lower capacity of force generation in the sphenomandibularis compared to the anterior temporalis. These characteristics are consistent with electromyographic findings on the functional differences between these two portions.

Subject

Lòbul temporal, Músculs, Articulació temporomandibular, Reacció en cadena de la polimerasa, Electromiografia

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Temporal lobe, Muscles, Temporomandibular joint, Polymerase chain reaction, Electromyography

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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CIURANA, Neus, et al. mRNA expression of myosin heavy chain isoforms in the sphenomandibularis portion of the temporalis muscle. International Journal of Morphology. 2022. Vol. 40, num. 3, pags. 728-734. ISSN 0717-9367. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/191742

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