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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/152536
Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor
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The bulbs and aerial parts of Zephyranthes concolor (Lindl.) Benth. & Hook. f. (Amaryllidaceae), an endemic species to Mexico, were found to contain the alkaloids chlidanthine, galanthamine, galanthamine N-oxide, lycorine, galwesine, and epinorgalanthamine. Since currently only partial and low resolution 1H-NMR data for chlidanthine acetate are available, and none for chlidanthine, its 1D and 2D high resolution 1H- and 13C-NMR spectra were recorded. Unambiguous assignations were achieved with HMBC, and HSQC experiments, and its structure was corroborated by X-ray diffraction. Minimum energy conformation for structures of chlidanthine, and its positional isomer galanthamine, were calculated by molecular modelling. Galanthamine is a well known acetylcholinesterase inhibitor; therefore, the isolated alkaloids were tested for this activity. Chlidanthine and galanthamine N-oxide inhibited electric eel acetylcholinesterase (2.4 and 2.6 × 10−5 M, respectively), indicating they are about five times less potent than galanthamine, while galwesine was inactive at 10−3 M. Inhibitory activity of HIV-1 replication, and cytotoxicity of the isolated alkaloids were evaluated in human MT-4 cells; however, the alkaloids showed poor activity as compared with standard anti-HIV drugs, but most of them were not cytotoxic.
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REYES-CHILPA, Ricardo, BERKOV, Strahil, HERNÁNDEZ-ORTEGA, Simón, JANKOWSKI, Christopher k., ARSENEAU, Sebastien, CLOTET-CODINA, Imma, ESTÉ, José a., CODINA MAHRER, Carles, VILADOMAT MEYA, Francesc, BASTIDA ARMENGOL, Jaume. Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor. _Molecules_. 2011. Vol. 16, núm. 11, pàgs. 9520-9533. [consulta: 21 de gener de 2026]. ISSN: 1420-3049. [Disponible a: https://hdl.handle.net/2445/152536]