Miniatura

Fitxers

698885.pdf (3.37 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2018-01-05

Llicència de publicació

cc-by (c) Caro Maldonado, Alfredo et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/167962

Low-dose statin treatment increases prostate cancer aggressiveness

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.18632/oncotarget.22217

Resum

Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. Here we show that treatment with anti-cholesterolemic drugs, statins, at doses achieved in patients, enhance the pro-tumorigenic activity of obesogenic diets. In addition, the use of a mouse model of prostate cancer and human prostate cancer xenografts revealed that in vivo simvastatin administration alone increases prostate cancer aggressiveness. In vitro cell line systems supported the notion that this phenomenon occurs, at least in part, through the direct action on cancer cells of low doses of statins, in range of what is observed in human plasma. In sum, our results reveal a prostate cancer experimental system where statins exhibit an undesirable effect, and warrant further research to address the relevance and implications of this observation in human prostate cancer.

Matèries

Colesterol, Obesitat, Càncer de pròstata

Matèries (anglès)

Cholesterol, Obesity, Prostate cancer

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

CARO MALDONADO, Alfredo, CAMACHO, Laura, ZABALA LETONA, Amaia, TORRANO, Verónica, FERNÁNDEZ RUIZ, Sonia, ZAMACOLA-BASCARAN, Kepa, ARREAL, Leire, VALCÁRCEL-JIMÉNEZ, Lorea, MARTÍN-MARTÍN, Natalia, FLORES, Juana maría, CORTAZAR, Ana rosa, ZÚÑIGA GARCÍA, Patricia, ARRUABARRENA-ARISTORENA, Amaia, GUILLAUMOND, Fabienne, CABRERA, Diana, FALCÓN PÉREZ, Juan m., ARANSAY, Ana m., GOMEZ-MUÑOZ, Antonio, OLIVAN RIERA, Mireia, MOROTE, Juan, CARRACEDO, Arkaitz. Low-dose statin treatment increases prostate cancer aggressiveness. _Oncotarget_. 2018. Vol. 9, núm. 2, pàgs. 1494-1504. [consulta: 28 de gener de 2026]. ISSN: 1949-2553. [Disponible a: https://hdl.handle.net/2445/167962]

Exportar metadades

JSON - METS

Compartir registre