Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió enviadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/170234
Inhibitors of lipogenic enzymes as a potential therapy against cancer
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore commonly enhanced in many cancer cell lines. Thus, relevant efforts are being made by the scientific community to inhibit the enzymes involved in lipid metabolism to disrupt cancer cell proliferation. We review the rapidly expanding body of inhibitors that target lipid metabolism, their side effects, and current status in clinical trials as potential therapeutic approaches against cancer. We focus on their molecular, biochemical and structural properties, selectivity and effectiveness and discuss their potential role as antitumor drugs. Keywords: cancer drugs; lipid metabolism; lipogenic enzyme inhibitors.
Matèries (anglès)
Citació
Citació
MONTESDEOCA, Nicolás, LÓPEZ, Marta, ARIZA PIQUER, Xavier, HERRERO RODRÍGUEZ, Laura, MAKOWSKI, Kamil. Inhibitors of lipogenic enzymes as a potential therapy against cancer. _The FASEB Journal _. 2020. Vol. 34, núm. 9, pàgs. 11355-11381. [consulta: 23 de gener de 2026]. ISSN: 0892-6638. [Disponible a: https://hdl.handle.net/2445/170234]