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2020

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/170234

Inhibitors of lipogenic enzymes as a potential therapy against cancer

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Recurs relacionat

https://doi.org/10.1096/fj.202000705R

Resum

Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore commonly enhanced in many cancer cell lines. Thus, relevant efforts are being made by the scientific community to inhibit the enzymes involved in lipid metabolism to disrupt cancer cell proliferation. We review the rapidly expanding body of inhibitors that target lipid metabolism, their side effects, and current status in clinical trials as potential therapeutic approaches against cancer. We focus on their molecular, biochemical and structural properties, selectivity and effectiveness and discuss their potential role as antitumor drugs. Keywords: cancer drugs; lipid metabolism; lipogenic enzyme inhibitors.

Matèries

Enzims, Metabolisme dels lípids, Medicaments antineoplàstics

Matèries (anglès)

Enzymes, Lipid metabolism, Antineoplastic agents

Citació

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

MONTESDEOCA, Nicolás, et al. Inhibitors of lipogenic enzymes as a potential therapy against cancer. The FASEB Journal . 2020. Vol. 34, num. 9, pags. 11355-11381. ISSN 0892-6638. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/170234

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