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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/176303
Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
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The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.
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CAMILLERI ROBLES, Carlos, SERRAS RIGALT, Florenci and COROMINAS, Montserrat (Corominas Guiu). Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila. Genes. 2019. Vol. 10, num. 5, pags. 378. ISSN 2073-4425. [consulted: 7 of June of 2026]. Available at: https://hdl.handle.net/2445/176303