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Published version

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2016-09-06

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cc-by-nc-nd (c) Reigada Sanz, Ramon, 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/101698

Alteration of interleaflet coupling due to compounds displaying rapid translocation in lipid membranes

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http://dx.doi.org/10.1038/srep32934

Abstract

The spatial coincidence of lipid domains at both layers of the cell membrane is expected to play an important role in many cellular functions. Competition between the surface interleaflet tension and a line hydrophobic mismatch penalty are conjectured to determine the transversal behavior of laterally heterogeneous lipid membranes. Here, by a combination of molecular dynamics simulations, a continuum field theory and kinetic equations, I demonstrate that the presence of small, rapidly translocating molecules residing in the lipid bilayer may alter its transversal behavior by favoring the spatial coincidence of similar lipid phases.

Subject

Membranes lipídiques, Dinàmica molecular

Subject (English)

Lipid membranes, Molecular dynamics

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Articles publicats en revistes (Ciència dels Materials i Química Física)

Citation

REIGADA SANZ, Ramon. Alteration of interleaflet coupling due to compounds displaying rapid translocation in lipid membranes. Scientific Reports. 2016. Vol. 6, num. 32934. ISSN 2045-2322. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/101698

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