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2002-01-28

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/225922

Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-erythritol2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli

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https://doi.org/10.1016/S0040-4039(01)02269-9

Abstract

In the bacterium Escherichiacoli, gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-3H]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-3H]methylerythritol 2,4-cyclodiphosphate. This suggests that the GCPE protein is involved in the further conversion of methylerythritol cyclodiphosphate into isoprenoids.

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Metabolisme microbià, Escheríchia coli

Subject (English)

Microbial metabolism, Escherichia coli

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citation

SEEMANN, Myriam, et al. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-erythritol2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli. Tetrahedron Letters. 2002. Vol. 43, num. 5, pags. 775-778. ISSN 0040-4039. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/225922

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