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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/157976
The Critical role of codon composition on the translation efficiency robustness of the Hepatitis A virus capsid
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Hepatoviruses show an intriguing deviated codon usage, suggesting an evolutionary signature. Abundant and rare codons in the cellular genome are scarce in the human hepatitis A virus (HAV) genome, while intermediately abundant host codons are abundant in the virus. Genotype-phenotype maps, or fitness landscapes, are a means of representing a genotype position in sequence space and uncovering how genotype relates to phenotype and fitness. Using genotype-phenotype maps of the translation efficiency, we have shown the critical role of the HAV capsid codon composition in regulating translation and determining its robustness. Adaptation to an environmental perturbation such as the artificial induction of cellular shutoff not naturally occurring in HAV infection involved movements in the sequence space and dramatic changes of the translation efficiency. Capsid rare codons, including abundant and rare codons of the cellular genome, slowed down the translation efficiency in conditions of no cellular shutoff. In contrast, rare capsid codons that are abundant in the cellular genome were efficiently translated in conditions of shutoff. Capsid regions very rich in slowly translated codons adapt to shutoff through sequence space movements from positions with highly robust translation to others with diminished translation robustness. These movements paralleled decreases of the capsid physical and biological robustness, and resulted in the diversification of capsid phenotypes. The deviated codon usage of extant hepatoviruses compared with that of their hosts may suggest the occurrence of a virus ancestor with an optimized codon usage with respect to an unknown ancient host.
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D'ANDREA RODRÍGUEZ-VIDA, Lucía, PÉREZ-RODRÍGUEZ, Francisco javier, CASTELLARNAU SERRA, Montserrat de, GUIX ARNAU, Susana, RIBES MORA, Enric, QUER, Josep, GREGORI FONT, Josep, BOSCH, Albert, PINTÓ SOLÉ, Rosa maría. The Critical role of codon composition on the translation efficiency robustness of the Hepatitis A virus capsid. _Genome Biology and Evolution_. 2019. Vol. 11, núm. 9, pàgs. 2439-2456. [consulta: 23 de gener de 2026]. ISSN: 1759-6653. [Disponible a: https://hdl.handle.net/2445/157976]