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Accepted version

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2014-02-05

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/52728

Identification of metabolites and thermal transformation products of quinolones in raw cow milk by liquid chromatography coupled to high resolution mass spectrometry.

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http://dx.doi.org/10.1021/jf405554z

Abstract

The presence of residues of antibiotics, metabolites, and thermal transformation products (TPs), produced during thermal treatment to eliminate pathogenic microorganisms in milk, could represent a risk for people. Cow"s milk samples spiked with enrofloxacin (ENR), ciprofloxacin (CIP), difloxacin (DIF), and sarafloxacin (SAR) and milk samples from cows medicated with ENR were submitted to several thermal treatments. The milk samples were analyzed by liquid chromatography-mass spectrometry (LC-MS) to find and identify TPs and metabolites. In this work, 27 TPs of 4 quinolones and 24 metabolites of ENR were found. Some of these compounds had been reported previously, but others were characterized for the first time, including lactose-conjugated CIP, the formamidation reaction for CIP and SAR, and hydroxylation or ketone formation to produce three different isomers for all quinolones studied.

Subject

Metabòlits, Quinolones, Llet, Cromatografia de líquids, Espectrometria de masses, Antibiòtics, Tractament tèrmic

Subject (English)

Metabolites, Quinolone antibacterial agents, Milk, Liquid chromatography, Mass spectrometry, Antibiotics, Heat treatment

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Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citation

JUNZA MARTÍNEZ, Alexandra, et al. Identification of metabolites and thermal transformation products of quinolones in raw cow milk by liquid chromatography coupled to high resolution mass spectrometry. Journal of Agricultural and Food Chemistry. 2014. Vol. 62, num. 8, pags. 2008-2021. ISSN 0021-8561. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/52728

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