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2024-01-01

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cc-by (c) Mozas, Pablo et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/218127

A low total metabolic tumor volume independently predicts for a longer time to first treatment in initially observed, low tumor burden follicular lymphoma

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https://doi.org/10.1002/hon.3235

Resum

Watchful waiting is an acceptable management strategy for advanced-stage, low tumor burden (LTB) patients with follicular lymphoma (FL). However, the prediction of how long this treatment-free observation period will last remains imperfect. We explored whether total metabolic tumor volume (TMTV) and other positron emission tomography parameters were predictive of time to first treatment (TTFT). We analyzed 97 grade 1-3A advanced-stage LTB FL patients and found that a high TMTV was associated with other tumor burden features at diagnosis. Patients with a TMTV above our established cutoff of 50 mL had a significantly shorter median duration of observation (2.6 vs. 8.8 years; p = 0.001). At 5 years, 77% of patients with a high TMTV and 46% of patients with a low TMTV required treatment. In the multivariable analysis, a high TMTV was the only independent factor predicting TTFT (hazard ratio = 2.09; p = 0.017). Overall, TMTV is a strong predictor of the duration of observation in LTB FL patients. Upon validation of our cutoff in external series and standardization of the methodology, the TMTV could become an additional factor to consider deferring or initiating treatment in otherwise LTB patients.

Matèries

Limfomes, Tomografia, Tumors

Matèries (anglès)

Lymphomas, Tomography, Tumors

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Articles publicats en revistes (Fonaments Clínics)

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MOZAS, Pablo, CASANUEVA ELICEIRY, Sebastián, RIVERO, Andrea, SERNA, Ángel, SIMÓ, Marc, RODRÍGUEZ, Sara, RIVAS DELGADO, Alfredo, NADEU PRAT, Ferran, CORREA, Juan gonzalo, PIÑEYROA, Juan antonio, PÉREZ VALENCIA, Amanda isabel, GUINETTI ORTIZ, Katia, GÓMEZ HERNANDO, Marta, GINÉ SOCA, Eva, DELGADO GONZÁLEZ, Julio, VILLAMOR I CASAS, Neus, CAMPO GÜERRI, Elias, MAGNANO, Laura, ABRISQUETA COSTA, Pau, SETOAIN PEREGO, Xavier, LÓPEZ GUILLERMO, Armando. A low total metabolic tumor volume independently predicts for a longer time to first treatment in initially observed, low tumor burden follicular lymphoma. _Hematological Oncology_. 2024. Vol. 42, núm. 1. [consulta: 21 de gener de 2026]. ISSN: 0278-0232. [Disponible a: https://hdl.handle.net/2445/218127]

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