Miniatura

Fitxers

679875.pdf (557.89 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2016-10-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172444

European phase II study of mogamulizumab, an anti-CCR4 monoclonal antibody, in relapsed/refractory peripheral T-cell lymphoma

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3324/haematol.2016.146977

Resum

CC chemokine receptor 4 (CCR4), the receptor for macrophage-derived chemokine (MDC/CCL22) and thymus activation-regulated chemokine (TARC/CCL17), is expressed on tumor cells in approximately 30-65% of patients with peripheral T-cell lymphoma (PTCL).1 Mogamulizumab, a defucosylated, humanized, IgG1 monoclonal antibody directed against CCR4 has been approved in Japan for the treatment of CCR4-positive relapsed/refractory PTCL. Mogamulizumab demonstrated effectiveness [overall response rate (ORR) 34%] in a phase II study of 29 Japanese patients with relapsed CCR4-positive PTCL.2 We conducted a phase II study in patients with relapsed or refractory CCR4-positive PTCL at 15 European centers (clinicaltrials.gov identifier :01611142). All patients gave written informed consent prior to enrollment. The study was conducted in accordance with the Declaration of Helsinki and in compliance with Good Clinical Practice guidelines. The protocol was approved by the Ethics Committee at each participating institution. The primary objective was to determine the best ORR of mogamulizumab. Secondary objectives included the duration of response, progression-free survival (PFS), and overall survival (OS) as well as the safety and immunogenicity of mogamulizumab.

Matèries

Cèl·lules T, Limfomes, Europa

Matèries (anglès)

T cells, Lymphomas, Europe

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)

Citació

ZINZANI, Pier luigi, KARLIN, Lionel, RADFORD, John, CABALLERO, Dolores, FIELDS, Paul, CHAMULEAU, Martine e. d., D'AMORE, Francesco, HAIOUN, Corinne, THIEBLEMONT, Catherine, GONZÁLEZ BARCA, Eva, GRANDE, Carlos, Johnson Peter W., IMHOFF, Gustaaf w. van, NG, Thomas, DWYER, Karen, MORSCHHAUSER, Franck. European phase II study of mogamulizumab, an anti-CCR4 monoclonal antibody, in relapsed/refractory peripheral T-cell lymphoma. _Haematologica_. 2016. Vol. 101, núm. 10, pàgs. 407-410. [consulta: 25 de febrer de 2026]. ISSN: 0390-6078. [Disponible a: https://hdl.handle.net/2445/172444]

Exportar metadades

JSON - METS

Compartir registre