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2023-01

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cc by-nc-nd (c) Cabana Domínguez, Judit et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/194202

The translational genetics of ADHD and related phenotypes in model organisms

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Recurs relacionat

https://doi.org/10.1016/j.neubiorev.2022.104949

Resum

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder resulting from the interaction between genetic and environmental risk factors. It is well known that ADHD co-occurs frequently with other psychiatric disorders due, in part, to shared genetics factors. Although many studies have contributed to delineate the genetic landscape of psychiatric disorders, their specific molecular underpinnings are still not fully understood. The use of animal models can help us to understand the role of specific genes and environmental stimuli-induced epigenetic modifications in the pathogenesis of ADHD and its comorbidities. The aim of this review is to provide an overview on the functional work performed in rodents, zebrafish and fruit fly and highlight the generated insights into the biology of ADHD, with a special focus on genetics and epigenetics. We also describe the behavioral tests that are available to study ADHD-relevant phenotypes and comorbid traits in these models. Furthermore, we have searched for new models to study ADHD and its comorbidities, which can be useful to test potential pharmacological treatments.

Matèries

Peix zebra, Epigenètica, Rosegadors, Trastorns per dèficit d'atenció amb hiperactivitat en els adults, Trastorns per dèficit d'atenció amb hiperactivitat en els infants

Matèries (anglès)

Zebra danio, Epigenetics, Rodents, Attention deficit disorder with hyperactivity in adults, Attention deficit disorder with hyperactivity in children

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Col·leccions

Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

CABANA DOMÍNGUEZ, Judit, ANTÓN GALINDO, Ester, FERNÀNDEZ CASTILLO, Noèlia, SINGGIHE, Euginia l., O'LEARY, Aet, NORTON, William h.g., STREKALOVA, Tatyana, SCHENCKE, Annette, REIF, Andreas, LESCH, Klaus peter, SLATTERY, David, CORMAND RIFÀ, Bru. The translational genetics of ADHD and related phenotypes in model organisms. _Neuroscience and Biobehavioral Reviews_. 2023. Vol. 144, núm. 104949. [consulta: 31 de gener de 2026]. ISSN: 0149-7634. [Disponible a: https://hdl.handle.net/2445/194202]

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