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2016-03-10

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cc-by (c) Molins Monteys, Blanca et al., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/112425

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants

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https://doi.org/10.1038/srep22889

Abstract

Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the pathophysiological importance of the prototypical acute-phase reactant in the etiology of the disease is unknown, and data regarding the exact role of CRP in ocular inflammation are limited. In this study, we provide mechanistic insight into how CRP contributes to the development of AMD. In particular, we show that monomeric CRP (mCRP) but not the pentameric form (pCRP) upregulates IL-8 and CCL2 levels in retinal pigment epithelial cells. Further, we show that complement factor H (FH) binds mCRP to dampen its proinflammatory activity. FH from AMD patients carrying the 'risk' His402 polymorphism displays impaired binding to mCRP, and therefore proinflammatory effects of mCRP remain unrestrained.

Subject

Inflamació, Malalties de la retina, Degeneració (Patologia), Malalties de les persones grans

Subject (English)

Inflammation, Retinal diseases, Degeneration (Pathology), Older people diseases

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

MOLINS MONTEYS, Blanca, et al. Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants. Scientific Reports. 2016. Vol. 6, num. 22889, pags. 1-12. ISSN 2045-2322. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/112425

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