A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging

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dc.contributor.authorFernandez, Antonio
dc.contributor.authorKielland, Nicola
dc.contributor.authorMakda, Ashraff
dc.contributor.authorCarragher, Neil
dc.contributor.authorGonzález-García, M. Carmen
dc.contributor.authorEspinar-Barranco, Laura
dc.contributor.authorGonzález-Vera, Juan Antonio
dc.contributor.authorOrte, Ángel
dc.contributor.authorLavilla Grífols, Rodolfo
dc.contributor.authorVendrell, Marc
dc.date.accessioned2022-12-15T12:12:04Z
dc.date.available2022-12-15T12:12:04Z
dc.date.issued2022-08-28
dc.date.updated2022-12-15T12:12:04Z
dc.description.abstractWe report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec724484
dc.identifier.issn2227-9059
dc.identifier.urihttps://hdl.handle.net/2445/191606
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1039/d2cb00168c
dc.relation.ispartofBiomedicines, 2022
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/771443/EU//DYNAFLUORS
dc.relation.urihttps://doi.org/10.1039/d2cb00168c
dc.rightscc-by (c) Fernandez, Antonio et al., 2022
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationQuímica farmacèutica
dc.subject.classificationSíntesi orgànica
dc.subject.otherPharmaceutical chemistry
dc.subject.otherOrganic synthesis
dc.titleA multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)