Carregant...
Tipus de document
Treball de fi de grauData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/48842
Synthesis of gold(I) organometallic compounds with potential biological activity
Títol de la revista
Autors
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
One of the main interest of alkynylgold(I) compounds are their therapeutic properties, especially their activity as anticancer agents. This TFG focuses on the synthesis of water-soluble alkynylgold(I) organometallic derivatives that could present biological activity as anticancer agents.
Preliminary experiments with related compounds (derivatives with diphosphine ligands containing phenyl substituents), have shown promising results that could be improved by increasing the solubility in water of the complexes. The reason is that these present important water-solubility problems that preclude their use as drugs.
The introduction of polar functional groups on the ligands has been studied, to determine which functionalized phosphines show more promise as ligands for both water-soluble mononuclear and binuclear gold(I) complexes. Subsequently synthesis of monophosphine ligand Ph2PCH2OH (1b) and diphosphine [1,2-bis(hydroxymethylphenylphosphino)ethane] (hmppe) (1a) was undertaken with successful results...
Descripció
Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2012, Directora: Montserrat Ferrer Garcia
Matèries (anglès)
Citació
Col·leccions
Citació
TEJERO IBORRA, M. àngels. Synthesis of gold(I) organometallic compounds with potential biological activity. [consulta: 25 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/48842]