Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/187141
Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, thousands of relatively similar compounds should be prepared along the drug discovery process. In this respect, heterocycle‐based multicomponent reactions offer advantages over traditional stepwise sequences in terms of synthetic economy, as well as the fast access to chemsets to study the structure activity relationships, the fine tuning of properties, and the preparation of larger amounts for preclinical phases. In this account, we briefly summarize the scientific methodology backing the research line followed by the group. We comment on the main results, clustered according to the targets and, finally, in the conclusion section, we offer a general appraisal of the situation and some perspectives regarding future directions in academic and private research.
Subject (English)
Citation
Citation
NADAL RODRÍGUEZ, Pau, et al. Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design. Biomedicines. 2022. Vol. 10, num. 1488-1507. ISSN 2227-9059. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/187141