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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222578
Could a supplementation with Bifidobacterium infantis in formula milk prevent ADHD development?
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[eng] Attention deficit and hyperactivity disorder (ADHD) is a condition which affects a large number of children and adolescents worldwide, with a prevalence that continues to increase. Traditionally, it has been attributed to hereditary genetic factors, however, in the last few decades, other elements that influence the development of the disorder have been studied. This new approach has led to the exploration of alternative therapies beyond conventional ones and has generated growing interest in the search for more effective long-term treatments.
The thesis focuses on the aetiology of ADHD and, in particular, on the impact of the gut microbiota on the onset of the disorder. It is worth highlighting the presence of dysbiosis as a common feature in many environmental risk factors, which suggests a possible involvement in the development of this condition. To better understand the impact of the gut microbiota on neurodevelopment, its relationship with the brain has been analysed through the microbiota-gut-brain axis. Finally, the study explores the influence of breastfeeding on the formation of the infant microbiota and its associated benefits.
A systematic literature search was conducted using Pubmed, SpringerLink, Scopus, ScienceDirect and Nature. Additionally, in-person and online interviews were carried out with specialists from different fields: a gastroenterologist, a paediatrician, a child psychiatrist and a researcher from Danone specialised in infant microbiota and a sales-representative from Nutribiótica.
The findings underline the importance of neuroinflammation in the development of ADHD. This process is often the result of chronic inflammation, promoted by dysbiosis, especially in formula-fed children. Supplementation with Bifidobacterium infantis in infants has been shown to have a positive effect on the development of the immune system through modulation of the inflammatory response. Furthermore, B. infantis contributes to the healthy formation of the intestinal microbiota.
In conclusion, although further research is required, current evidence suggest that B. infantis supplementation in formula milk could contribute to preventing the development of ADHD.
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Treballs Finals del Doble Grau de Farmàcia i Nutrició Humana i Dietètica de la Facultat Farmàcia i Ciències de l’Alimentació,Facultat Farmàcia i Ciències de l’Alimentació. Universitat de Barcelona. Curs: 2024-2025. Tutor: Raquel Martín Venegas.
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MARINÉ SANTOS, Ana. Could a supplementation with Bifidobacterium infantis in formula milk prevent ADHD development?. [consulta: 27 de novembre de 2025]. [Disponible a: https://hdl.handle.net/2445/222578]