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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/165232
1H-NMR Urinary Metabolic Profile, A Promising Tool for the Management of Infants with Human Cytomegalovirus-Infection
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Abstract: Congenital human cytomegalovirus (HCMV) infection is the most common mother-to-child transmitted infection in the developed world. Certain aspects of its management remain a challenge. Urinary metabolic profiling is a promising tool for use in pediatric conditions. The aim of this study was to investigate the urinary metabolic profile in HCMV-infected infants and controls during acute care hospitalization. Urine samples were collected from 53 patients at five hospitals participating in the Spanish congenital HCMV registry. Thirty-one cases of HCMV infection and 22 uninfected controls were included. Proton nuclear magnetic resonance (1H-NMR) spectra were obtained using NOESYPR1D pulse sequence. The dataset underwent orthogonal projection on latent structures discriminant analysis to identify candidate variables affecting the urinary metabolome: HCMV infection, type of infection, sex, chronological age, gestational age, type of delivery, twins, and diet. Statistically significant discriminative models were obtained only for HCMV infection (p = 0.03) and chronological age (p < 0.01). No significant differences in the metabolomic profile were found between congenital and postnatal HCMV infection. When the HCMV-infected group was analyzed according to chronological age, a statistically significant model was obtained only in the neonatal group (p = 0.01), with the differentiating metabolites being betaine, glycine, alanine, and dimethylamine. Despite the considerable variation in urinary metabolic profiles in a real-life setting, clinical application of metabolomics to the study of HCMV infection seems feasible.
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FRICK, Marie antoinette, BARBA, Ignasi, FENOY-ALEJANDRE, Marina, LÓPEZ-LÓPEZ, Paula, BAQUERO ARTIGAO, Fernando, RODRÍGUEZ-MOLINO, Paula, NOGUERA JULIAN, Antoni, NICOLÁS-LÓPEZ, Marta, DE LA FUENTE-JUÁREZ, Asunción, CODINA GRAU, Maria gemma, ESPERALBA ESQUERRA, Juliana, LINDE-SILLO, Ángeles, SOLER PALACÍN, Pere. 1H-NMR Urinary Metabolic Profile, A Promising Tool for the Management of Infants with Human Cytomegalovirus-Infection. _Metabolites_. 2019. Vol. 9, núm. 288. [consulta: 24 de gener de 2026]. ISSN: 2218-1989. [Disponible a: https://hdl.handle.net/2445/165232]