A novel redox cycle diverts cells from oncogene-induced senescence into cancer

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dc.contributor.authorMaus, Mate
dc.contributor.authorSerrano Marugán, Manuel
dc.date.accessioned2022-02-04T16:54:15Z
dc.date.available2022-09-21T05:10:21Z
dc.date.issued2021-09-21
dc.date.updated2022-02-02T16:58:18Z
dc.description.abstractIgelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Copyright © 2021 Elsevier Inc. All rights reserved.ca
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idimarina6533990
dc.identifier.issn1097-4164
dc.identifier.pmid34547231
dc.identifier.urihttps://hdl.handle.net/2445/182935
dc.language.isoengca
dc.publisherElsevierca
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.molcel.2021.08.023
dc.relation.ispartofMolecular Cell, 2021, vol 81, num 18, 3672-3674
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/669622/EU//CELLPLASTICITY
dc.relation.urihttps://doi.org/10.1016/j.molcel.2021.08.023
dc.rightscc by-nc-nd (c) Elsevier, 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject.classificationMetabolisme cel·lular
dc.subject.classificationOncogens
dc.subject.otherCell metabolism
dc.subject.otherOncogenes
dc.titleA novel redox cycle diverts cells from oncogene-induced senescence into cancerca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
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