Tipus de document
AltresVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/201023
Cancer stem cells revisited
Títol de la revista
Autors
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated stem cells. It has gradually become clear that many tumors harbor CSCs in dedicated niches, and yet their identification and eradication has not been as obvious as was initially hoped. Recently developed lineage-tracing and cell-ablation strategies have provided insights into CSC plasticity, quiescence, renewal, and therapeutic response. Here we discuss new developments in the CSC field in relationship to changing insights into how normal stem cells maintain healthy tissues. Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging.
Matèries
Matèries (anglès)
Citació
Citació
BATLLE, Eduard and CLEVERS, Hans. Cancer stem cells revisited. Nature Medicine. 2017. Vol. 23, num. 10, pags. 1124-1134. ISSN 1546-170X. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/201023