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2020-09-15

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cc-by (c) Miró Martí, Ma. Lluïsa et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/171579

Dietary Supplementation with Spray-Dried Porcine Plasma Attenuates Colon Inflammation in a Genetic Mouse Model of Inflammatory Bowel Disease

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https://doi.org/10.3390/ijms21186760

Abstract

Dietary supplementation with spray-dried porcine plasma (SDP) can modulate the immune response of gut-associated lymphoid tissue. SDP supplementation reduces acute mucosal inflammation, as well as chronic inflammation associated with aging. The aim of this study was to analyze if SDP supplementation could ameliorate colitis in a genetic mouse model of inflammatory bowel disease (IBD). Wild-type mice and Mdr1a knockout (KO) mice were administered a control diet or an SDP-supplemented diet from day 21 (weaning) until day 56. The histopathological index, epithelial barrier, and intestinal immune system were analyzed in the colonic mucosa. KO mice had higher epithelial permeability, increased Muc1 and Muc4 expression, and lower abundance of E-cadherin and Muc2 (all p < 0.001). SDP prevented these effects (all p < 0.05) and decreased the colonic inflammation observed in KO mice, reducing neutrophil and monocyte infiltration and activation and the percentage of activated T helper lymphocytes in the colonic mucosa (all p < 0.05). SDP also diminished proinflammatory cytokine expression and increased the anti-inflammatory IL-10 concentration in the colonic mucosa (all p < 0.05). In conclusion, dietary supplementation with SDP enhances colon barrier function and reduces mucosal inflammation in a mouse model of IBD.

Subject

Colitis, Experimentació animal, Malalties inflamatòries intestinals

Subject (English)

Colitis, Animal experimentation, Inflammatory bowel diseases

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citation

MIRÓ MARTÍ, Ma. Lluïsa, et al. Dietary Supplementation with Spray-Dried Porcine Plasma Attenuates Colon Inflammation in a Genetic Mouse Model of Inflammatory Bowel Disease. International Journal of Molecular Sciences. 2020. Vol. 21, num. 18, pags. 6760. ISSN 1661-6596. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/171579

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