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Systemic AA amyloidosis caused by inflammatory hepatocellular adenoma

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dc.contributor.authorCalderaro, Julien
dc.contributor.authorLetouzé, Eric
dc.contributor.authorBayard, Quentin
dc.contributor.authorBoulai, Anais
dc.contributor.authorRenault, Victor
dc.contributor.authorDeleuze, Jean-François
dc.contributor.authorBestard Matamoros, Oriol
dc.contributor.authorFranco, Dominique
dc.contributor.authorZafrani, Elie-Serge
dc.contributor.authorNault, Jean-Charles
dc.contributor.authorMoutschen, Michel
dc.contributor.authorZucman-Rossi, Jessica
dc.date.accessioned2021-06-16T17:00:45Z
dc.date.available2021-06-16T17:00:45Z
dc.date.issued2018-09-20
dc.date.updated2021-06-16T17:00:46Z
dc.description.abstractTo the Editor: Amyloid A (AA) systemic amyloidosis is a complication of chronic inflammatory diseases that is caused by the deposition of insoluble aggregates of cleaved N-terminal fragments of serum amyloid A (SAA) protein in tissues and organs throughout the body. Under physiologic conditions, SAA protein is produced by hepatocytes during the acute inflammatory phase in response to various cytokines such as interleukin-6. SAA is also overexpressed by neoplastic hepatocytes in inflammatory hepatocellular adenomas, a specific molecular subtype of benign liver tumors.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec685156
dc.identifier.issn0028-4793
dc.identifier.pmid30231230
dc.identifier.urihttps://hdl.handle.net/2445/178468
dc.language.isoeng
dc.publisherMassachusetts Medical Society
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1056/NEJMc1805673
dc.relation.ispartofNew England Journal of Medicine, 2018, vol. 379, num. 12, p. 1178-1180
dc.relation.urihttps://doi.org/10.1056/NEJMc1805673
dc.rights(c) Massachusetts Medical Society, 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Ciències Clíniques)
dc.subject.classificationFetge
dc.subject.classificationAmiloïdosi
dc.subject.classificationSèrum
dc.subject.classificationProteïnes
dc.subject.otherLiver
dc.subject.otherAmyloidosis
dc.subject.otherSerum
dc.subject.otherProteins
dc.titleSystemic AA amyloidosis caused by inflammatory hepatocellular adenoma
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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