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2024-06

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cc-by-nc-nd (c) Gonçalves-Ribeiro, Joana et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/218451

Adenosine receptors are the on-and-off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex

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https://doi.org/10.1002/glia.24518

Resum

The medial prefrontal cortex (mPFC) is involved in cognitive functions such as work- ing memory. Astrocytic cannabinoid type 1 receptor (CB1R) induces cytosolic calcium (Ca2+) concentration changes with an impact on neuronal function. mPFC astrocytes also express adenosine A1 and A2A receptors (A1R, A2AR), being unknown the cross- talk between CB1R and adenosine receptors in these cells. We show here that a fur- ther level of regulation of astrocyte Ca2+ signaling occurs through CB1R-A2AR or CB1R-A1R heteromers that ultimately impact mPFC synaptic plasticity. CB1R- mediated Ca2+ transients increased and decreased when A1R and A2AR were acti- vated, respectively, unveiling adenosine receptors as modulators of astrocytic CB1R. CB1R activation leads to an enhancement of long-term potentiation (LTP) in the mPFC, under the control of A1R but not of A2AR. Notably, in IP3R2KO mice, that do not show astrocytic Ca2+ level elevations, CB1R activation decreases LTP, which is not modified by A1R or A2AR. The present work suggests that CB1R has a homeo- static role on mPFC LTP, under the control of A1R, probably due to physical crosstalk between these receptors in astrocytes that ultimately alters CB1R Ca2+ signaling.

Matèries

Adenosina, Astròcits

Matèries (anglès)

Adenosine, Astrocytes

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

GONÇALVES-RIBEIRO, Joana, et al. Adenosine receptors are the on-and-off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex. Glia. 2024. Vol. 72, num. 6, pags. 1096-1116. ISSN 0894-1491. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/218451

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