Propolis for Herpes simplex lesions: Review of the evidence and design of a lipstick for its application

Abstract

Propolis is a natural substance produced by bees that show equal or more efficacy than acyclovir on herpes lesions. Mechanism of the antiviral action seems to be blocking the virus entrance into the cell. In addition, other actions related to relieving associated symptomatology like pain, tension and burning sensation, are of interest. Some major constituents present in propolis have been identified as active, such as galangin, chrysin, pinocembrin, benzoic acid, caffeic acid and coumaric acid. Nevertheless, the activity of the isolated compounds was ever lower than for the mixture of the propolis constituents. Some of the most used propolis extracts in antiviral activity experimentation with herpes lesions are ethanolic extracts and aqueous extracts. They differ in composition, action time and efficacy, despite in both cases efficacy in front placebo and acyclovir was demonstrated. On the market, different propolis lip balms could be found, but no propolis lipstick, making it a commercial opportunity. In order to design a propolis lipstick proposal, a propolis extraction with propylene glycol, was prepared and used on the lipstick. Final formula take into account different needs of a person who suffers from cold-sore as a little bit of sun protection, nutriment, hide the lesion and have a good sensation at the organoleptic level.