Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/166323
In silico evidence that protein unfolding is as a precursor of the protein aggregation
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
We present a computational study on the folding and aggregation of proteins in an aqueous environment, as a function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration results in the complete loss of the folded structures and induces the formation of protein aggregates. We discuss the effect of the protein interface on the water fluctuations in the protein hydration shell and their relevance in the protein‐protein interaction.
Matèries (anglès)
Citació
Citació
BIANCO, Valentino, FRANZESE, Giancarlo i COLUZZA, Ivan. In silico evidence that protein unfolding is as a precursor of the protein aggregation. Chemphyschem. 2019. Vol. 21, núm. 5, pàgs. 377-384. ISSN 1439-4235. [consulta: 8 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/166323