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2015-04-21

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cc-by (c) Batlle, M. et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/67308

Astroglia-microglia cross talk during neurodegeneration in the rat hippocampus

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http://dx.doi.org/10.1155/2015/102419

Resum

Brain injury triggers a progressive inflammatory response supported by a dynamic astroglia-microglia interplay. We investigated the progressive chronic features of the astroglia-microglia cross talk in the perspective of neuronal effects in a rat model of hippocampal excitotoxic injury. N-Methyl-D-aspartate (NMDA) injection triggered a process characterized within 38 days by atrophy, neuronal loss, and fast astroglia-mediated S100B increase. Microglia reaction varied with the lesion progression. It presented a peak of tumor necrosis factor-α (TNF-α) secretion at one day after the lesion, and a transient YM1 secretion within the first three days. Microglial glucocorticoid receptor expression increased up to day 5, before returning progressively to sham values. To further investigate the astroglia role in the microglia reaction, we performed concomitant transient astroglia ablation with L-α-aminoadipate and NMDA-induced lesion. We observed a striking maintenance of neuronal death associated with enhanced microglial reaction and proliferation, increased YM1 concentration, and decreased TNF-α secretion and glucocorticoid receptor expression. S100B reactivity only increased after astroglia recovery. Our results argue for an initial neuroprotective microglial reaction, with a direct astroglial control of the microglial cytotoxic response. We propose the recovery of the astroglia-microglia cross talk as a tissue priority conducted to ensure a proper cellular coordination that retails brain damage.

Matèries

Micròglia, Malalties neurodegeneratives, Rates (Animals de laboratori)

Matèries (anglès)

Microglia, Neurodegenerative Diseases, Rats as laboratory animals

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Articles publicats en revistes (Ciències Fisiològiques)

Citació

BATLLE, Montserrat, et al. Astroglia-microglia cross talk during neurodegeneration in the rat hippocampus. BioMed Research International. 2015. Vol. 2015, num. 1-15. ISSN 2314-6133. [consulted: 2 of June of 2026]. Available at: https://hdl.handle.net/2445/67308

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