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Data de publicació

2004-05-15

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/47366

Snail blocks the cell cycle and confers resistance to cell death

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Recurs relacionat

http://dx.doi.org/10.1101/gad.294104

Resum

The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.

Matèries

Mort cel·lular, Embriologia, Trastorns del desenvolupament, Animals, Éssers humans, Apoptosi

Matèries (anglès)

Cell death, Embryology, Developmental disabilities, Animals, Human beings, Apoptosis

Citació

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)

Citació

VEGA, Sonia, et al. Snail blocks the cell cycle and confers resistance to cell death. Genes & Development. 2004. Vol. 18, num. 1131-1143. ISSN 0890-9369. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/47366

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