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Requena-Mendez_A_J_Antimicrob_Chemother_2018.pdf (235.86 KB)

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2018-11-08

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/128328

Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid

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Recurs relacionat

http://dx.doi.org/ 10.1093/jac/dky444

Resum

Background: Poor response to TB therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic parameters can be affected by comorbidities or the interaction of drugs with food. Objectives: This study aimed to determine the effect of food intake upon pharmacokinetics of rifampicin and isoniazid in a Peruvian population with TB. Methods: Rifampicin and isoniazid levels were analysed at 2, 4 and 6 h after drug intake in both fasting and non-fasting states using LC-MS methods. Results: Sixty patients participated in the study. The median rifampicin Cmax and AUC0–6 were higher during fasting than non-fasting: 7.02 versus 6.59 mg/L (P = 0.054) and 28.64 versus 24.31 mg·h/L (P = 0.002). There was a statistically significant delay overall of non-fasting Tmax compared with the fasting state Tmax (P = 0.005). In the multivariate analysis, besides the effect of fasting, Cmax for females was 20% higher than for males (P = 0.03). Concerning isoniazid, there were significant differences in the Cmax during non-fasting (median = 3.51 mg/L) compared with fasting (4.54 mg/L). The isoniazid dose received had an effect upon the isoniazid levels (1.26, P = 0.038). In the multivariate analysis, isoniazid exposure during fasting was found to be 14% higher than during non-fasting (CI = 1.02–1.28, P < 0.001). Neither radiological extent of the disease nor consumption of food with drug intake nor pharmacokinetics of rifampicin or isoniazid was associated with a poorer treatment outcome. Conclusions: Rifampicin in particular and isoniazid pharmacokinetics were significantly affected by the intake of the drug with food between and within individuals.

Matèries

Tuberculosi, Farmacocinètica

Matèries (anglès)

Tuberculosis, Pharmacokinetics

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Articles publicats en revistes (ISGlobal)

Citació

REQUENA-MÉNDEZ, Ana, et al. Intra-individual effects of food upon the pharmacokinetics of                rifampicin and isoniazid. Journal of Antimicrobial Chemotherapy. 2019. Vol. 74, num. 2, pags. 416–424. ISSN 0305-7453. [consulted: 23 of August of 2026]. Available at: https://hdl.handle.net/2445/128328

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