Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure

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dc.contributor.authorBenabou Zdaou, Sanae
dc.contributor.authorGaravís, Miguel
dc.contributor.authorLyonnais, Sébastien
dc.contributor.authorEritja i Casadellà, Ramon
dc.contributor.authorGonzález, Carlos
dc.contributor.authorGargallo Gómez, Raimundo
dc.date.accessioned2019-02-05T13:25:32Z
dc.date.available2019-02-05T13:25:32Z
dc.date.issued2016-02-09
dc.date.updated2019-02-05T13:25:32Z
dc.description.abstractThe nature and length of loops connecting cytosine tracts in i-motif structures may affect their stability. In this work, the influence of the nature of the nucleobases located in two of the loops of an intramolecular i-motif is studied using spectroscopy, separation techniques, and multivariate data analysis. Insertion of bases other than thymine induces an additional acid-base equilibrium with pKa~4.5. The presence of two guanine bases in the loops, placed opposite to each other, decreases the thermal stability of the structure. In contrast, thymine and cytosine bases in these positions stabilize the structure
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec656926
dc.identifier.issn1463-9076
dc.identifier.pmid26957024
dc.identifier.urihttps://hdl.handle.net/2445/127915
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1039/C5CP07428B
dc.relation.ispartofPhysical Chemistry Chemical Physics, 2016, vol. 18, num. 11, p. 7997-8004
dc.relation.urihttps://doi.org/10.1039/C5CP07428B
dc.rights(c) Benabou Zdaou, Sanae et al., 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject.classificationADN
dc.subject.classificationEspectroscòpia de ressonància magnètica nuclear
dc.subject.classificationCromatografia de permeació per gel
dc.subject.classificationElectroforesi
dc.subject.otherDNA
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.subject.otherGel permeation chromatography
dc.subject.otherElectrophoresis
dc.titleUnderstanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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